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Identifying the mechanism of action (MOA) of novel or Obviously occurring compounds generally depends on assays customized for individual goal proteins. Right here we explore an alternate strategy based upon sample matching reaction profiles acquired working with cultured neuronal networks. Cono
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Electrode voltage signals were being substantial-pass filtered at three hundred Hz following which spikes had been detected with custom made Matlab scripts based upon precision timing spike detection19 with spikes staying detected if the peak amplitude was increased than six moments the c